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Sign Up for FORCE NewslettersInformation for People with an Inherited Mutation
People with an in have increased risk for certain cancers, including:
- breast
- ovarian
- pancreatic
People with a mutation have options for screening, prevention and treatment of . There are expert guidelines and clinical trials that focus on:
- screening and early detection
- risk-reduction
- treatment
The expert guidelines are updated every year based the results of new research.
There may be other medical concerns for people with a mutation, including a rare childhood disease known as Fanconi anemia which can happen in people who inherit a mutation in both copies of their gene.
Each of these topics is outlined in more detail in the sections highlighted below.
More Information on Mutations
Cancer Risks
Cancer risk estimates are updated based on the latest research. Read about the lifetime risk for different cancers in people with inherited mutations.
Risk Management Options
Read about the latest expert guidelines for cancer screening and prevention for people with a mutation. Learn about research studies enrolling high-risk patients.
Cancer Treatment Options
Tumor testing and genetic testing can provide additional clues about which treatments may work best for your cancer. People who test positive for a mutation may have additional treatment or clinical trial options available to them.
Other Considerations
People who inherit a mutation in both copies of their gene—one from each parent—have a rare disease known as Fanconi anemia. Learn additional information about inherited mutations.
Participate in Prevention Research
The screening and prevention studies below are enrolling people with mutations. To search for more studies, visit our Search and Enroll Tool.
Testing a Vaccine for Cancer Prevention in People with a BRCA1 or BRCA2 Mutation
Clinicaltrials.gov identifier:
NCT04367675
Clinicaltrials.gov identifier:
NCT05287451
Pancreatic Cancer Early Detection for People at High Risk
Clinicaltrials.gov identifier:
NCT04970056
Testing a Vaccine for Preventing or Treating Triple-Negative Breast Cancer
Clinicaltrials.gov identifier:
NCT04674306
Participate in Treatment Research
The treatment studies below are enrolling people with mutations. To search for more studies, visit our Search and Enroll Tool.
Clinicaltrials.gov identifier:
NCT04858334
Combination ATR inhibitor and PARP Inhibitor in Recurrent Ovarian Cancer (CAPRI)
Clinicaltrials.gov identifier:
NCT03462342
Clinicaltrials.gov identifier:
NCT04584255
Clinicaltrials.gov identifier:
NCT04548752
Clinicaltrials.gov identifier:
NCT04038502
Watch Our Webinar for People with Mutations
Webinar: Cancer Risks, Screening and Prevention for People with BRCA1 or BRCA2 Mutations